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Article

Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate Cancer

4 Jul 2025

Abstract excerpt

Prostate cancer (PCa) is a highly heterogeneous disease, with castration-resistant prostate cancer (CRPC) and neuroendocrine prostate cancer (NEPC) representing its most aggressive and therapy-resistant forms. Emerging evidence indicates that lineage plasticity-driven by key transcription factors such as Octamer Binding Factor 4 (OCT4)-plays a crucial role in therapeutic resistance and disease progression. OCT4,...

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PMID: 40722714
DOI: 10.3390/biomedicines13071642

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