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Article

A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network

10 Aug 2018

Abstract excerpt

BACKGROUND: Prostate adenocarcinoma (AdPC) cells can undergo lineage switching to neuroendocrine cells and develop into therapy-resistant neuroendocrine prostate cancer (NEPC). While genomic/epigenetic alterations are shown to induce neuroendocrine differentiation via an intermediate stem-like state, RNA splicing factor SRRM4 can transform AdPC cells into NEPC xenografts through a direct neuroendocrine...

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PMID: 30100395
DOI: 10.1016/j.ebiom.2018.08.011

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