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Article

Expression of Pluripotent Stem Cell Reprogramming Factors by Prostate Tumor Initiating Cells

23 Mar 2010

Abstract excerpt

PURPOSE: We identified a discrete population of stem cell-like tumor cells expressing 5 essential transcription factors required to reprogram pluripotency in prostate tumor cell lines and primary prostate cancer tissue. MATERIALS AND METHODS: DU145 and PC3 human prostate cancer cell lines (ATCC), tumor tissue from patients with prostate cancer and normal prostate tissue were evaluated for the reprogramming...

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PMID: 20303530
DOI: 10.1016/j.juro.2009.12.092

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