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Article

LIN28B promotes the development of neuroendocrine prostate cancer

7 Jul 2020

Abstract excerpt

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can develop when prostate adenocarcinoma cells acquire cancer stem-like cell signaling in the presence of androgen receptor inhibition, followed by redifferentiation toward neuroendocrine lineage and subsequent t-NEPC progression. Whether the...

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PMID: 32634132
DOI: 10.1172/jci135373

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