Article
Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
Endocrine journal - 1 Jan 2012
Hishida Asahi, Morita Emi, Naito Mariko, Okada Rieko, Wakai Kenji, Matsuo Keitaro, Nakamura Kazuyo, Takashima Naoyuki, Suzuki Sadao, Takezaki Toshiro, Mikami Haruo, Ohnaka Keizo, Watanabe Yoshiyuki, Uemura Hirokazu, Kubo Michiaki, Tanaka Hideo, Hamajima Nobuyuki
Abstract excerpt
This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative...