Article
Lack of a requirement for strict rotational alignment among transcription factor binding sites in yeast.
Nucleic acids research - 11 Jun 1991
Inokuchi K, Nakayama A
Abstract excerpt
The MF alpha 1 gene of Saccharomyces cerevisiae is an alpha specific gene whose expression is regulated by two upstream activation sites (UASMF alpha 1S), which are the binding sites for activator proteins, MAT alpha 1 and MCM1. UASMF alpha 1 elements act in a synergistic fashion; lack of either element causes reduced expression levels that are 6- to 45-fold less than that of intact promoter in alpha cells. We...
Topics
- Base Sequence
- Binding Sites
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Plasmids
- RNA, Fungal
- RNA, Messenger
- Saccharomyces cerevisiae
- TATA Box