Article
A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an alpha 2 dimer.
Cell - 10 Jan 1992
Smith D L, Johnson A D
Abstract excerpt
DNA recognition sequences for dimeric proteins typically contain two types of information. The first is the DNA sequence of each half-site, and the second is the arrangement of these half-sites. We show that dimers of the yeast homeodomain protein alpha 2, although able to read the first type of information, lack the ability to assess the second type. Rather, alpha 2 dimers bind with equal affinity to artificial...
Topics
- Base Sequence
- Cloning, Molecular
- DNA, Fungal
- DNA-Binding Proteins
- Escherichia coli
- Fungal Proteins
- Genetic Variation
- Homeodomain Proteins
- Macromolecular Substances
- Models, Structural
- Molecular Sequence Data