Article
The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding.
Molecular and cellular biology - 1 Jan 1999
Jin Y, Zhong H, Vershon A K
Abstract excerpt
In diploid cells of the yeast Saccharomyces cerevisiae, the alpha2 and a1 homeodomain proteins bind cooperatively to sites in the promoters of haploid cell-type-specific genes (hsg) to repress their expression. Although both proteins bind to the DNA, in the alpha2 homeodomain substitutions of residues that are involved in contacting the DNA have little or no effect on repression in vivo or cooperative DNA binding...
Topics
- Consensus Sequence
- DNA
- DNA-Binding Proteins
- Dimerization
- Fungal Proteins
- Homeodomain Proteins
- Minor Histocompatibility Antigens
- Mutagenesis
- Operator Regions, Genetic
- Phenotype
- Proto-Oncogene Proteins c-bcl-2