Article
No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies.
Genes, chromosomes & cancer - 1 Mar 2009
da Costa Cristiana E T, Szuhai Karoly, van Eijk Ronald, Hoogeboom Manja, Sciot Raphael, Mertens Fredrik, Björgvinsdóttir Helga, Debiec-Rychter Maria, de Krijger Ronald R, Hogendoorn Pancras C W, Egeler R Maarten, Annels Nicola E
Abstract excerpt
The etiology of Langerhans cell histiocytosis (LCH), a disease characterized by uncontrolled proliferation of Langerhans cells, is unknown. Although some believe that LCH is reactive, others support a neoplastic origin. We tested the hypothesis that LCH is neoplastic by investigating potential consistent chromosomal aberrations in LCH cells. We used multiparameter DNA flow cytometry to analyze the DNA ploidy LCH...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.