Article
Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease.
The New England journal of medicine - 21 Jul 1994
Willman C L, Busque L, Griffith B B, Favara B E, McClain K L, Duncan M H, Gilliland D G
Abstract excerpt
BACKGROUND: The lesions of Langerhans'-cell histiocytosis (histiocytosis X), a proliferative histiocytic disorder of unknown cause, contain histiocytes similar in phenotype to dendritic Langerhans' cells. The disease ranges in severity from a fatal leukemia-like disorder to an isolated lytic lesion of bone. Intermediate forms of the disease are usually characterized by multiorgan involvement, diabetes insipidus,...
Topics
- Adolescent
- Adult
- Alleles
- Base Sequence
- Child
- Child, Preschool
- Clone Cells
- DNA Primers
- DNA Probes
- Female
- Histiocytes
- Histiocytosis, Langerhans-Cell