Article
Frequency of MAP2K1, TP53, and U2AF1 Mutations in BRAF-mutated Langerhans Cell Histiocytosis: Further Characterizing the Genomic Landscape of LCH.
The American journal of surgical pathology - 1 Jul 2018
McGinnis Lisa M, Nybakken Grant, Ma Lisa, Arber Daniel A
Abstract excerpt
Langerhans cell histiocytosis is a proliferative disorder of neoplastic Langerhans cells with activating mutations in the Erk signaling pathway. TP53 and U2AF1 mutations have been implicated in other myelomonocytic malignancies and we hypothesized that mutations in these genes may cosegregate in LCH patients according to BRAF mutation status. Towards this end, we collected cases with a pathologic diagnosis of...
Topics
- Adolescent
- Adult
- California
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry