Article
CDKN2A/B Deletion and Double-hit Mutations of the MAPK Pathway Underlie the Aggressive Behavior of Langerhans Cell Tumors.
The American journal of surgical pathology - 1 Feb 2018
Xerri Luc, Adélaïde José, Popovici Cornel, Garnier Séverine, Guille Arnaud, Mescam-Mancini Lenaïg, Laurent Camille, Brousset Pierre, Coze Carole, Michel Gérard, Chaffanet Max, Bouabdallah Reda, Coso Diane, Bertucci François, Birnbaum Daniel
Abstract excerpt
Langerhans cell histiocytosis (LCH) has a mostly favorable outcome, whereas Langerhans cell sarcoma (LCS) is an aggressive tumor. It is still unclear whether any specific molecular alterations could underlie the aggressive behavior of Langerhans cell proliferations. We used targeted next-generation sequencing and array-comparative genomic hybridization to profile 22 LCH samples from different patients together...
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