Article
Adenovirus-mediated transfer of tissue-type plasminogen activator augments thrombolysis in tissue-type plasminogen activator-deficient and plasminogen activator inhibitor-1-overexpressing mice.
Blood - 15 Aug 1997
Carmeliet P, Stassen J M, Van Vlaenderen I, Meidell R S, Collen D, Gerard R D
Abstract excerpt
Impaired fibrinolysis, resulting from increased plasminogen activator inhibitor-1 (PAI-1) or reduced tissue-type plasminogen activator (t-PA) plasma levels, may predispose the individual to subacute thrombosis in sepsis and inflammation. The objective of these studies was to show that adenovirus-...
Topics
- Adenoviridae
- Alleles
- Animals
- Cells, Cultured
- Fibrinolysis
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Humans
- Mice
- Mice, Transgenic
- Plasminogen Activator Inhibitor 1
- Recombinant Proteins
- Thrombosis
- Tissue Plasminogen Activator