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Article

Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.

Neoplasia (New York, N.Y.) - 1 Dec 2008

Michael Lowell Evan, Westerman Bart A, Ermilov Alexandre N, Wang Aiqin, Ferris Jennifer, Liu Jianhong, Blom Marleen, Ellison David W, van Lohuizen Maarten, Dlugosz Andrzej A

Abstract excerpt

Inappropriate Hedgehog (Hh) signaling underlies development of a subset of medulloblastomas, and tumors with elevated HH signaling activity express the stem cell self-renewal gene BMI1. To test whether Bmi1 is required for Hh-driven medulloblastoma development, we varied Bmi1 gene dosage in transgenic mice expressing an oncogenic Hh effector, SmoA1, driven by a glial fibrillary acidic protein (GFAP) promoter....

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Source

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Identifiers

PMID: 19048113
DOI: 10.1593/neo.81078
PMCID: PMC2586685

Genes

GFAP
BMI1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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