Article
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration.
PloS one - 1 Jan 2008
Seitsonen Sanna P, Onkamo Päivi, Peng Gang, Xiong Momiao, Tommila Petri V, Ranta Päivi H, Holopainen Juha M, Moilanen Jukka A, Palosaari Tapani, Kaarniranta Kai, Meri Seppo, Immonen Ilkka R, Järvelä Irma E
Abstract excerpt
BACKGROUND: Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries. METHODS/PRINCIPAL FINDINGS: We investigated the association between the LOC387715 A69S and complement component C3 R102G risk alleles in the Finnish case-control material and found a...
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