Article
Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.
Cell reports - 21 Mar 2017
Vo BaoHan T, Li Chunliang, Morgan Marc A, Theurillat Ilan, Finkelstein David, Wright Shaela, Hyle Judith, Smith Stephanie M C, Fan Yiping, Wang Yong-Dong, Wu Gang, Orr Brent A, Northcott Paul A, Shilatifard Ali, Sherr Charles J, Roussel Martine F
Abstract excerpt
The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-, and trimethylase of polycomb-repressive complex 2. Ezh2 has a context-dependent role in different cancers as an oncogene or tumor suppressor and retards tumor progression in a mouse model of G3 MB. Engineered deletions of Ezh2 in G3 MBs by gene editing...
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