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CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

24 Oct 2016

Abstract excerpt

Medulloblastoma (MB), the most common malignant paediatric brain tumor, is currently treated using a combination of surgery, craniospinal radiotherapy and chemotherapy. Owing to MB stem cells (MBSCs), a subset of MB patients remains untreatable despite standard therapy. CD133 is used to identify MBSCs although its functional role in tumorigenesis has yet to be determined. In this work, we showed enrichment of...

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PMID: 27775079
DOI: 10.1038/onc.2016.235

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