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Article

Medulloblastoma in Adults: Cytogenetic Phenotypes Identify Prognostic Subgroups.

Journal of neuropathology and experimental neurology - 16 Apr 2021

Goschzik Tobias, Zur Muehlen Anja, Doerner Evelyn, Waha Andreas, Friedrich Carsten, Hau Peter, Pietsch Torsten

Abstract excerpt

Adult medulloblastomas (MB) are rare. We investigated the genetic landscape and prognostic impact of genetic aberrations in a cohort of 117 adult medulloblastomas. Histological features and pathway activation were evaluated at the protein level; 14.5% showed wingless-type activation, 63.3% SHH activation, and 22.2% were classified as non-WNT/non-SHH-MB. Genome-wide copy number analysis was performed by molecular...

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Identifiers

PMID: 33870422
DOI: 10.1093/jnen/nlab020

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