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Article

Mutation of the Conserved Threonine 8 within the Human ARF Tumour Suppressor Protein Regulates Autophagy.

Biomolecules - 13 Jan 2022

Fontana Rosa, Guidone Daniela, Angrisano Tiziana, Calabrò Viola, Pollice Alessandra, La Mantia Girolama, Vivo Maria

Abstract excerpt

BACKGROUND: The ARF tumour suppressor plays a well-established role as a tumour suppressor, halting cell growth by both p53-dependent and independent pathways in several cellular stress response circuits. However, data collected in recent years challenged the traditional role of this protein as a tumour suppressor. Cancer cells expressing high ARF levels showed that its expression, far from being dispensable, is...

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Identifiers

PMID: 35053274
DOI: 10.3390/biom12010126
PMCID: PMC8773949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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