Mutation of the Conserved Threonine 8 within the Human ARF Tumour Suppressor Protein Regulates Autophagy.

doi:10.3390/biom12010126

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Article

Mutation of the Conserved Threonine 8 within the Human ARF Tumour Suppressor Protein Regulates Autophagy.

Biomolecules - 13 Jan 2022

Fontana Rosa, Guidone Daniela, Angrisano Tiziana, Calabrò Viola, Pollice Alessandra, La Mantia Girolama, Vivo Maria

Abstract excerpt

BACKGROUND: The ARF tumour suppressor plays a well-established role as a tumour suppressor, halting cell growth by both p53-dependent and independent pathways in several cellular stress response circuits. However, data collected in recent years challenged the traditional role of this protein as a tumour suppressor. Cancer cells expressing high ARF levels showed that its expression, far from being dispensable, is...

Topics

Autophagy
HeLa Cells
Humans
Mutation
Threonine
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53
Tumor Suppressor Proteins

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Identifiers

PMID: 35053274
DOI: 10.3390/biom12010126
PMCID: PMC8773949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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