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Article

FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2008

Mehta Parinda A, Gerbing Robert B, Alonzo Todd A, Elliott James S, Zamzow Tiffany A, Combs Michelle, Stover Emily, Ross Julie A, Perentesis John P, Meschinchi Soheil, Lange Beverly J, Davies Stella M

Abstract excerpt

PURPOSE: FAS is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down-regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine transition in the FAS promoter region (position -1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease FAS...

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Identifiers

PMID: 19047119
DOI: 10.1158/1078-0432.CCR-08-0418
PMCID: PMC2787450

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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