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Article

DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2009

Al-Shakfa Fidaa, Dulucq Stéphanie, Brukner Ivan, Milacic Iva, Ansari Marc, Beaulieu Patrick, Moghrabi Albert, Laverdière Caroline, Sallan Stephen E, Silverman Lewis B, Neuberg Donna, Kutok Jeffery L, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

PURPOSE: Dihydrofolate reductase (DHFR) is the major target of methotrexate, a key component in childhood acute lymphoblastic leukemia (ALL) treatment. We recently reported an association of DHFR promoter polymorphisms with ALL outcome. Lower event-free survival correlated with haplotype *1, defined by A(-317) and C(-1610) alleles. Haplotype *1 was also associated higher DHFR expression. EXPERIMENTAL DESIGN:...

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Source

Identifiers

PMID: 19861437
DOI: 10.1158/1078-0432.CCR-09-0641

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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