A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia.

doi:10.1182/blood-2011-04-349803

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Article

A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia.

Blood - 5 Jan 2012

Sunter Nicola J, Scott Kathryn, Hills Robert, Grimwade David, Taylor Sheila, Worrillow Lisa J, Fordham Sarah E, Forster Victoria J, Jackson Graham, Bomken Simon, Jones Gail, Allan James M

Abstract excerpt

Up to 15% of acute promyelocytic leukemia (APL) patients fail to achieve or maintain remission. We investigated a common G > A polymorphism at position -1377 (rs2234767) in the core promoter of the CD95 cell death receptor gene in 708 subjects with acute myeloid leukemia, including 231 patients with APL. Compared with the GG genotype, carrier status for the -1377A variant was associated with a significantly worse...

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PMID: 22084312
DOI: 10.1182/blood-2011-04-349803

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