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Article

MDM2 polymorphism increases susceptibility to childhood acute myeloid leukemia: a report from the Children's Oncology Group.

Pediatric blood & cancer - 1 Aug 2010

Phillips Christine L, Gerbing Robert, Alonzo Todd, Perentesis John P, Harley Isaac T W, Meshinchi Soheil, Bhatla Deepika, Radloff Gretchen, Davies Stella M

Abstract excerpt

BACKGROUND: The variant polymorphism in the gene MDM2, SNP309, leads to increased level of mdm2 protein and subsequent downregulation of p53 tumor suppressor pathway. Presence of this single nucleotide polymorphism (SNP) has been associated with earlier tumorigenesis in patients with Li-Fraumeni syndrome, as well as decreased survival in patients with CLL. In addition, cells homozygous (G/G) for SNP 309 were...

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Identifiers

PMID: 20582981
DOI: 10.1002/pbc.22519
PMCID: PMC2915901

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDM2 polymorphism increases susceptibility to childhood acute myeloid leukemia: a report from the Children's Oncology Group.PMID 20582981Read ↗

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MDM2 SNP309 variation contributes to leukemia risk: meta-analyses based on 7259 subjects.Semantic proximity Read ↗

Association of MDM2 polymorphism with risk and prognosis of leukemia: a meta-analysis.Semantic proximity Read ↗

TP53 mutations and MDM2(SNP309) identify subgroups of AML patients with impaired outcome.Semantic proximity Read ↗

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MDM2 SNP309 and p53 codon 72 genetic polymorphisms and risk of AML: an Egyptian study.Semantic proximity Read ↗

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