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Article

Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate.

The Journal of biological chemistry - 6 Feb 2009

Egerer Martina, Giesemann Torsten, Herrmann Christian, Aktories Klaus

Abstract excerpt

Clostridium difficile toxins A and B are major virulence factors responsible for induction of pseudomembranous colitis and antibiotic-associated diarrhea in men. The toxins possess a multidomain structure and only the N-terminal glucosyltransferase domain, which inactivates Rho GTPases by glucosylation, is translocated into the cytosol of target cells. Processing of the toxin occurs by autocatalytic cleavage and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19047051
DOI: 10.1074/jbc.M806002200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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