Article
Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites.
The Journal of biological chemistry - 25 Sept 2009
Prochazkova Katerina, Shuvalova Ludmilla A, Minasov George, Voburka Zdenek, Anderson Wayne F, Satchell Karla J F
Abstract excerpt
The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins rel...
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