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Article

Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects.

Infection and immunity - 1 Oct 2006

Teichert Matthias, Tatge Helma, Schoentaube Janett, Just Ingo, Gerhard Ralf

Abstract excerpt

Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB up-regulation as a cellular stress response.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16988280
DOI: 10.1128/IAI.00545-06
PMCID: PMC1594915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects.PMID 16988280Read ↗

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