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Article

Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity.

The Journal of biological chemistry - 13 Mar 2020

Kang Chia-Yu, Huang I-Hsiu, Chou Chi-Chi, Wu Tsai-Yu, Chang Jyun-Cyuan, Hsiao Yu-Yuan, Cheng Cheng-Hsuan, Tsai Wei-Jiun, Hsu Kai-Cheng, Wang Shuying

Abstract excerpt

Most of Gram-positive bacteria anchor surface proteins to the peptidoglycan cell wall by sortase, a cysteine transpeptidase that targets proteins displaying a cell wall sorting signal. Unlike other bacteria, Clostridium difficile, the major human pathogen responsible for antibiotic-associated diarrhea, has only a single functional sortase (SrtB). Sortase's vital importance in bacterial virulence has been long...

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Identifiers

PMID: 32005667
DOI: 10.1074/jbc.RA119.011322
PMCID: PMC7076211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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