Article
Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
NeuroImage - 1 Mar 2009
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Avedissian Christina, Madsen Sarah K, Parikshak Neelroop, Toga Arthur W, Jack Clifford R, Schuff Norbert, Weiner Michael W, Thompson Paul M
Abstract excerpt
As one of the earliest structures to degenerate in Alzheimer's disease (AD), the hippocampus is the target of many studies of factors that influence rates of brain degeneration in the elderly. In one of the largest brain mapping studies to date, we mapped the 3D profile of hippocampal degeneration over time in 490 subjects scanned twice with brain MRI over a 1-year interval (980 scans). We examined baseline and...
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