Article
Cortical variability and asymmetry in normal aging and Alzheimer's disease.
Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 1998
Thompson P M, Moussai J, Zohoori S, Goldkorn A, Khan A A, Mega M S, Small G W, Cummings J L, Toga A W
Abstract excerpt
The onset of Alzheimer's disease (AD) is accompanied by a complex and distributed pattern of neuroanatomic change, difficult to distinguish clinically from dynamic alterations in normal aging. Extreme variations in the sulcal patterns of the human cortex have made it difficult to identify diffuse...
Topics
- Aged
- Aging
- Alzheimer Disease
- Atrophy
- Brain Mapping
- Cerebral Cortex
- Corpus Callosum
- Female
- Genetic Variation
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Models, Anatomic
- Models, Neurological
- Stereotaxic Techniques