Article
The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients.
Psychiatric genetics - 1 Aug 2008
Smits Kim M, Smits Luc J M, Peeters Frenk P M L, Schouten Jan S A G, Janssen Rob G J H, Smeets Hubert J M, van Os Jim, Prins Martin H
Abstract excerpt
BACKGROUND: Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors (SSRIs) effects. Quantitative assessment of genetic influences is necessary to evaluate whether genetic testing before antidepressant prescription would lead to earlier treatment effects. This study evaluates the influence of two polymorphisms...
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