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Article

Moderation of antidepressant response by the serotonin transporter gene.

The British journal of psychiatry : the journal of mental science - 1 Jul 2009

Huezo-Diaz Patricia, Uher Rudolf, Smith Rebecca, Rietschel Marcella, Henigsberg Neven, Marusic Andrej, Mors Ole, Maier Wolfgang, Hauser Joanna, Souery Daniel, Placentino Anna, Zobel Astrid, Larsen Erik Roj, Czerski Piotr M, Gupta Bhanu, Hoda Farzana, Perroud Nader, Farmer Anne, Craig Ian, Aitchison Katherine J, McGuffin Peter

Abstract excerpt

BACKGROUND: There have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene. AIMS: To test the hypothesis that the...

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Identifiers

PMID: 19567893
DOI: 10.1192/bjp.bp.108.062521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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