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Article

Brain Connectivity Changes in Autosomal Recessive Parkinson Disease: A Model for the Sporadic Form.

PloS one - 1 Jan 2016

Makovac Elena, Cercignani Mara, Serra Laura, Torso Mario, Spanò Barbara, Petrucci Simona, Ricciardi Lucia, Ginevrino Monia, Caltagirone Carlo, Bentivoglio Anna Rita, Valente Enza Maria, Bozzali Marco

Abstract excerpt

Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of various neuronal circuits. Using...

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Identifiers

PMID: 27788143
DOI: 10.1371/journal.pone.0163980
PMCID: PMC5082970

Genes

PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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