Contributions of phylogenetically variable structural elements to the function of the ribozyme ribonuclease P.

doi:10.1021/bi00117a003

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Article

Contributions of phylogenetically variable structural elements to the function of the ribozyme ribonuclease P.

Biochemistry - 21 Jan 1992

Darr S C, Zito K, Smith D, Pace N R

Abstract excerpt

Ribonuclease P (RNase P) is a ribonucleoprotein enzyme which participates in processing precursor tRNAs. The RNA subunit contains the catalytic site and is capable of catalysis in the absence of the protein subunit. RNase P RNAs from various eubacteria consist of a core of conserved sequence and...

Topics

Base Sequence
Catalysis
Endoribonucleases
Escherichia coli Proteins
Genetic Variation
Kinetics
Molecular Sequence Data
Mutagenesis, Insertional
Nucleic Acid Conformation
Phylogeny
RNA, Bacterial
RNA, Catalytic
Ribonuclease P
Structure-Activity Relationship
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 1370627
DOI: 10.1021/bi00117a003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1370627-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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