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Article

RNase P: role of distinct protein cofactors in tRNA substrate recognition and RNA-based catalysis.

Nucleic acids research - 1 Jan 2005

Sharin Ela, Schein Aleks, Mann Hagit, Ben-Asouli Yitzhak, Jarrous Nayef

Abstract excerpt

The Escherichia coli ribonuclease P (RNase P) has a protein component, termed C5, which acts as a cofactor for the catalytic M1 RNA subunit that processes the 5' leader sequence of precursor tRNA. Rpp29, a conserved protein subunit of human RNase P, can substitute for C5 protein in reconstitution assays of M1 RNA activity. To better understand the role of the former protein, we compare the mode of action of Rpp29...

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Identifiers

PMID: 16155184
DOI: 10.1093/nar/gki828
PMCID: PMC1201335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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