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Article

The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer.

RNA (New York, N.Y.) - 1 Jul 2011

Koutmou Kristin S, Day-Storms Jeremy J, Fierke Carol A

Abstract excerpt

Ribonuclease P (RNase P) catalyzes the metal-dependent 5' end maturation of precursor tRNAs (pre-tRNAs). In Bacteria, RNase P is composed of a catalytic RNA (PRNA) and a protein subunit (P protein) necessary for function in vivo. The P protein enhances pre-tRNA affinity, selectivity, and cleavage efficiency, as well as modulates the cation requirement for RNase P function. Bacterial P proteins share little...

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Identifiers

PMID: 21622899
DOI: 10.1261/rna.2742511
PMCID: PMC3138560

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Source receipt: pubmed, retrieved 7 Sept 2026.

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