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Article

Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa.

The Journal of antimicrobial chemotherapy - 1 Feb 2009

Mita Toshihiro, Tanabe Kazuyuki, Takahashi Nobuyuki, Culleton Richard, Ndounga Mathieu, Dzodzomenyo Mawuli, Akhwale Willis S, Kaneko Akira, Kobayakawa Takatoshi

Abstract excerpt

OBJECTIVES: Resistance to pyrimethamine in Plasmodium falciparum is conferred by mutations in the gene encoding dihydrofolate reductase (DHFR). It is known that DHFR double mutants have evolved independently in multiple geographic areas, whereas the triple mutant prevalent in Africa appears to have originated in south-east Asia. In this study, we investigated whether other triple mutants may have evolved...

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Source

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Identifiers

PMID: 19036751
DOI: 10.1093/jac/dkn482
PMCID: PMC2639266

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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