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Article

Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia.

Antimicrobial agents and chemotherapy - 1 Mar 2007

Mita Toshihiro, Tanabe Kazuyuki, Takahashi Nobuyuki, Tsukahara Takahiro, Eto Hideaki, Dysoley Lek, Ohmae Hiroshi, Kita Kiyoshi, Krudsood Srivicha, Looareesuwan Sornchai, Kaneko Akira, Björkman Anders, Kobayakawa Takatoshi

Abstract excerpt

Pyrimethamine resistance in Plasmodium falciparum has previously been shown to have emerged once in Southeast Asia, from where it spread to Africa. Pyrimethamine resistance in this parasite is known to be conferred by mutations in the gene encoding dihydrofolate reductase (dhfr). We have analyzed polymorphisms in dhfr as well as microsatellite haplotypes flanking this gene in a total of 285 isolates from...

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Identifiers

PMID: 17210777
DOI: 10.1128/AAC.01186-06
PMCID: PMC1803134

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Source receipt: pubmed, retrieved 7 Sept 2026.

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