Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced elimination of cyclosporine A in elderly (>65 years) kidney transplant recipients.

Transplantation - 27 Nov 2008

Falck Pål, Asberg Anders, Byberg Karen-Therese, Bremer Sara, Bergan Stein, Reubsaet Jan L E, Midtvedt Karsten

Abstract excerpt

BACKGROUND: Physiologic functions that may affect pharmacokinetics of drugs are altered in elderly patients. The current study was performed to elucidate the effect of age on cyclosporine A (CsA) pharmacokinetics in renal transplant recipients. METHOD: Twenty-five renal transplant recipients on CsA treatment were included in the study. CsA doses were adjusted by C2 monitoring. The patients were divided into two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclosporine

Share to Cytochrome P-450 CYP2A6

Share to Drug Administration Schedule

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Metabolic Clearance Rate

Source

Identifiers

PMID: 19034006
DOI: 10.1097/TP.0b013e31818aa4b6

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced elimination of cyclosporine A in elderly (>65 years) kidney transplant recipients.PMID 19034006Read ↗

Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia.Semantic proximity Read ↗

CYP3A5 polymorphism effect on cyclosporine pharmacokinetics in living donor renal transplant recipients: analysis by population pharmacokinetics.Semantic proximity Read ↗

No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation.Semantic proximity Read ↗

Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs.Semantic proximity Read ↗

Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients.Semantic proximity Read ↗

Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients.Semantic proximity Read ↗

Population pharmacokinetic study of cyclosporine in Chinese renal transplant recipients.Semantic proximity Read ↗

Association of CYP3A4*1B genotype with Cyclosporin A pharmacokinetics in renal transplant recipients: A meta-analysis.Semantic proximity Read ↗

Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients.Semantic proximity Read ↗

Polymorphisms of multidrug resistance gene (MDR1) and cyclosporine absorption in de novo renal transplant patients.Semantic proximity Read ↗

The Effect of ABCB1 C3435T Polymorphism on Cyclosporine Dose Requirements in Kidney Transplant Recipients: A Meta-Analysis.Semantic proximity Read ↗

A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.