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Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia.

Therapeutic drug monitoring - 1 Dec 2017

Cvetković Mirjana, Zivković Maja, Bundalo Maja, Gojković Ivana, Spasojević-Dimitrijeva Brankica, Stanković Aleksandra, Kostić Mirjana

Abstract excerpt

BACKGROUND: The interindividual variability of cyclosporin A (CsA) pharmacokinetics might be explained by heterogeneity in the cytochrome P450 3A (CYP3A) subfamily. Altered CYP3A enzyme activity was associated with variant allele of P450 oxidoreductase gene (POR*28). The aim of this study was to assess the impact of age, CYP3A5*3, CYP3A4*22, and POR*28 alleles on CsA pharmacokinetics in pediatric renal transplant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29135906
DOI: 10.1097/FTD.0000000000000442

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POR

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