Article
No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation.
European journal of clinical pharmacology - 1 Oct 2009
Miura Masatomo, Satoh Shigeru, Kagaya Hideaki, Saito Mitsuru, Inoue Takamitsu, Tsuchiya Norihiko, Suzuki Toshio, Habuchi Tomonori
Abstract excerpt
PURPOSE: The purpose of the study was to assess the impact of age on the pharmacokinetics of immunosuppressive drugs. METHODS: One hundred and ten renal transplant recipients, including 12 elderly patients over 60 years of age, 57 middle-aged patients between 40 and 59 years and 41 young adult patients 20 to 39 years of age were studied. To evaluate dose-adjusted pharmacokinetics and cytochrome P450 (CYP) 3A5...
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