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Article

Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways.

Bioinformatics (Oxford, England) - 15 Jan 2009

Chen Lina, Zhang Liangcai, Zhao Yan, Xu Liangde, Shang Yukui, Wang Qian, Li Wan, Wang Hong, Li Xia

Abstract excerpt

MOTIVATION: Complex diseases are generally thought to be under the influence of one or more mutated risk genes as well as genetic and environmental factors. Many traditional methods have been developed to identify susceptibility genes assuming a single-gene disease model ('single-locus methods'). Pathway-based approaches, combined with traditional methods, consider the joint effects of genetic factor and biologic...

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PMID: 19029127
DOI: 10.1093/bioinformatics/btn613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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