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Article

Prioritising risk pathways of complex human diseases based on functional profiling.

European journal of human genetics : EJHG - 1 Jun 2013

Li Yan, Huang Teng, Xiao Yun, Ning Shangwei, Wang Peng, Wang Qianghu, Chen Xin, Chaohan Xu, Sun Donglin, Li Xia, Li Yixue

Abstract excerpt

Analysis of the biological pathways involved in complex human diseases is an important step in elucidating the pathogenesis and mechanism of diseases. Most pathway analysis approaches identify disease-related biological pathways using overlapping genes between pathways and diseases. However, these approaches ignore the functional biological association between pathways and diseases. In this paper, we designed a...

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Identifiers

PMID: 23047740
DOI: 10.1038/ejhg.2012.218
PMCID: PMC3658188

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