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Article

Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network.

Genome biology - 1 Jan 2009

Linghu Bolan, Snitkin Evan S, Hu Zhenjun, Xia Yu, Delisi Charles

Abstract excerpt

We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are...

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Identifiers

PMID: 19728866
DOI: 10.1186/gb-2009-10-9-r91
PMCID: PMC2768980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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