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Article

Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels.

Development (Cambridge, England) - 1 Dec 2008

Schwank Gerald, Restrepo Simon, Basler Konrad

Abstract excerpt

Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation. Contrary to previous models, which implicated the slope of the Dpp gradient as an essential driver of cell proliferation, we find that the juxtaposition of cells with...

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Identifiers

PMID: 19029041
DOI: 10.1242/dev.025635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels.PMID 19029041Read ↗

Dynamics of Dpp signaling and proliferation control.Semantic proximity Read ↗

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker.Semantic proximity Read ↗

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.Semantic proximity Read ↗

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The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.Semantic proximity Read ↗

Growth control by a moving morphogen gradient during Drosophila eye development.Semantic proximity Read ↗

Wingless promotes proliferative growth in a gradient-independent manner.Semantic proximity Read ↗

Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing.Semantic proximity Read ↗

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker.Semantic proximity Read ↗

Notch signaling directly controls cell proliferation in the Drosophila wing disc.Semantic proximity Read ↗

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