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Article

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.

Cell - 19 Feb 1999

Jaźwińska A, Kirov N, Wieschaus E, Roth S, Rushlow C

Abstract excerpt

decapentaplegic (dpp), a Drosophila member of the TGFbeta family of secreted molecules, functions as a long-range morphogen in patterning of the embryo and the adult appendages. Dpp signals via the SMAD proteins Mad and Medea. Here we show that in the absence of brinker (brk), Mad is not required for the activation of Dpp target genes that depend on low levels of Dpp. brk encodes a novel protein with features of...

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Identifiers

PMID: 10052458
DOI: 10.1016/s0092-8674(00)80660-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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