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Article

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker.

The EMBO journal - 15 Nov 2000

Sivasankaran R, Vigano M A, Müller B, Affolter M, Basler K

Abstract excerpt

The gradient morphogen Decapentaplegic (Dpp) organizes pattern by inducing the transcription of different target genes at distinct threshold concentrations during Drosophila development. An important, albeit indirect, mode by which Dpp controls the spatial extent of its targets is via the graded downregulation of brinker, whose product in turn negatively regulates the expression of these targets. Here we report...

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Identifiers

PMID: 11080162
DOI: 10.1093/emboj/19.22.6162
PMCID: PMC305821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker.PMID 11080162Read ↗

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.Semantic proximity Read ↗

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