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Article

Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques.

Experimental eye research - 1 Mar 2009

Singh Krishna K, Krawczak Michael, Dawson William W, Schmidtke Joerg

Abstract excerpt

Age-related macular degeneration (AMD) is a clinically heterogeneous disease and constitutes the major cause of visual impairment in the elderly population worldwide. Rhesus macaques also possess a macula and, like humans, develop drusen-associated, age-related macular pathologies. Susceptibility to AMD in humans and drusen formation in rhesus macaques both have been shown to be associated with variation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19028492
DOI: 10.1016/j.exer.2008.10.019

Genes

HTRA1
ARMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques.PMID 19028492Read ↗

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Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular DegenerationSemantic proximity Read ↗

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration.Semantic proximity Read ↗

HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.Semantic proximity Read ↗

1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?Semantic proximity Read ↗

The Phenotypic Course of Age-Related Macular Degeneration for ARMS2/HTRA1: The EYE-RISK Consortium.Semantic proximity Read ↗

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degenerationSemantic proximity Read ↗

Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease.Semantic proximity Read ↗

Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology.Semantic proximity Read ↗

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read ↗

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