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Article

Rhesus monkeys and humans share common susceptibility genes for age-related macular disease.

Human molecular genetics - 1 Sept 2008

Francis Peter J, Appukuttan Binoy, Simmons Emily, Landauer Noelle, Stoddard Jonathan, Hamon Sara, Ott Jurg, Ferguson Betsy, Klein Michael, Stout J Timothy, Neuringer Martha

Abstract excerpt

Age-related macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision loss in the elderly, is associated with polymorphisms in the LOC387715/ARMS2 and HTRA1 genes on 10q26. Like humans, macaque monkeys possess a macula and develop age-related macular pathologies including drusen, the phenotypic hallmark of AMD. We genotyped a cohort of 137 unrelated rhesus macaques with and...

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Source

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Identifiers

PMID: 18535016
DOI: 10.1093/hmg/ddn167
PMCID: PMC2733804

Genes

ARMS2
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rhesus monkeys and humans share common susceptibility genes for age-related macular disease.PMID 18535016Read ↗

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