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Article

A polymorphism in the interleukin-10 promoter affects the course of disease in patients with clear-cell renal carcinoma.

Human immunology - 1 Jan 2009

Romero José María, Sáenz-López Pablo, Cózar José Manuel, Carretero Rafael, Canton Julia, Vazquez Fernando, Concha Angel, Tallada Miguel, Garrido Federico, Ruiz-Cabello Francisco

Abstract excerpt

In the tumor microenvironment, interleukin (IL)-10 production has a pleiotropic ability to positively and negatively influence the function of innate and adaptive immunity against cancer. This study investigated whether IL-10 genetic polymorphisms that influence gene expression levels play a role in the risk and clinical course of clear-cell renal cell carcinoma (RCC). We analyzed the allelic and haplotype...

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PMID: 19027043
DOI: 10.1016/j.humimm.2008.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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