Article
Cytokine gene polymorphisms, cancer susceptibility, and prognosis.
The Journal of nutrition - 1 Jan 2007
Howell W Martin, Rose-Zerilli Matthew J
Abstract excerpt
IL-10 is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions and may have both tumor-promoting and -inhibiting properties. A large number of polymorphisms (primarily single-nucleotide polymorphisms) have been identified in the IL10 gene promoter. Convincing evidence that certain of these polymorphisms are associated with differential expression of IL-10 in vitro and in some cases...
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